Technology & Advantages

The science that powers reliable diagnostics

Three proven technology platforms — stabilization, magnetic-bead extraction, and methylation detection — combine with manufacturing discipline to deliver reagents you can trust, batch after batch.

Our Technology

Three platforms, one continuous workflow

From the moment of collection to a decision-ready result, our platforms are engineered to protect analytes, maximize recovery, and keep every step reproducible.

Platform 01

cfDNA / cfRNA Stabilization Platform

Proprietary stabilizers inhibit nuclease activity and protect blood samples at ambient temperature, preserving cfDNA and cfRNA integrity from the point of draw through transport and storage.

  • Ambient stability — no cold chain required
  • Protects cfDNA, cfRNA, and whole-blood RNA
  • NGS & qPCR downstream compatible
Platform 02

Magnetic Bead Extraction Platform

High-yield magnetic-bead chemistry optimized for low-abundance nucleic acids across plasma, whole blood, urine, stool, swabs, and tissue — built for automated high-throughput workflows.

  • High purity and high recovery
  • Full automation compatibility
  • Unified workflow across sample types
Platform 03

Methylation Detection Platform

An integrated solution spanning bisulfite conversion, multiplex targeted methylation qPCR, and clear result interpretation — enabling sample-to-result workflows designed for early cancer screening.

  • Rapid bisulfite conversion protocols
  • Multiplex target analysis
  • Clear positive/negative calling
Compatibility

Adaptive methylation pre-processing solutions

Built to accept the sample types your lab already handles and to slot cleanly into your existing extraction or conversion instruments — using Aequivera reagents end-to-end or extending third-party platforms of your choice.

Multi-sample input Plasma Stool Urine Swab 200 µL – 4 mL
Scheme 1
End-to-end Aequivera
Automated extraction
Aequivera kit
Automated conversion
Aequivera kit
Downstream qPCR
Platform-adaptable
Scheme 2
Third-party extraction
Automated extraction
Third-party kit
Automated conversion
Aequivera kit
Downstream qPCR
Platform-adaptable
Scheme 3
Third-party conversion
Automated extraction
Aequivera kit
Automated conversion
Third-party kit
Downstream qPCR
Platform-adaptable
Note · Supports plasma, urine, stool and swab samples from 200 µL to 4 mL. Conversion performance is validated with Aequivera methylation kits as well as a broad set of third-party downstream PCR reagents commonly used in methylation screening.
All-in-one solution

Automated methylation pre-processing

Magnetic-bead chemistry paired with Aequivera extraction and conversion kits completes the sample-to-product workflow in roughly 1.5 hours — fully automated, no hands-on steps between start and finish.

Blood methylation automation

Whole-blood collection through stabilized preservation to an analyzer-ready convert-and-purify product.

1
Blood collection
7-day ambient stabilitycfDNA preservation tube· no cold chain · intact cells
2
Automated extraction
Large
~4 mL
Small
~200 µL
Magnetic bead · chloroform-free · no Proteinase K
3
Conversion & purification
PCR / water-bath dual-modeautomated purification · hands-free
⏱ Instant · no wait
⏱ 30 min
⏱ Conv. 30 + purify 30
Supports 200 µL – 4 mL sample volume, processing 24 or 32 samples per run. Conversion rate >99%, recovery rate >80% — product ready for downstream qPCR detection.

Stool methylation automation

Convenient stool sampling with built-in preservation buffer, run through a single automated extraction-plus-conversion path.

1
Sampling & prep
30-day stable bufferlyses & releases human and bacterial DNA
2
Auto extraction + conv.
One-stepmagnetic-bead automation completes extraction & bisulfite conversion
3
Conversion & purification
PCR / water-bath dual-modeautomated purification · ready for qPCR
⏱ Instant storage
⏱ <60 min
⏱ Conv. 30 + purify 30
Stool buffer stabilizes DNA for at least 30 days. With automated bead-based purification, conversion rate stays > 99% with high recovery, and the converted product runs directly on downstream methylation qPCR assays.

Explore how our technology fits your workflow

Request documentation, validation data, or evaluation samples for your laboratory.

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